Fig. 7

Siglec-15 knockdown attenuates pulmonary metastasis of osteosarcoma cells in vivo. a Representative images of lungs from the shSiglec-15 group and the control group. Different sizes of pulmonary metastases were quantitated on the basis of H&E staining results. b Immunohistochemistry results indicated the differences in the expression of Siglec-15, Beclin-1 and EMT markers (E-cadherin, vimentin) in lung metastases from the shSiglec-15 group and the control group. Representative images are shown at ×200 magnification