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Fig. 2 | Cell & Bioscience

Fig. 2

From: Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway

Fig. 2

Potential mechanisms that underlie the Siglec-15 associations with metastasis. a Heatmap of representative differentially expressed gene resulting from the control group and Siglec-15 knockdown group through transcriptomic sequencing. b A gene map of coexpression of these differentially expressed genes. c KEGG pathway analysis of differentially expressed genes revealed Siglec-15 associations with cell autophagy and migration. d Heatmap of differentially expressed genes, based on autophagy-related pathway analysis, revealed Siglec-15-mediated autophagy in osteosarcoma cells. e GSEA of the genes associated with the focal adhesion and cell adhesion molecules in control group and Siglec-15 knockdown group

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Cell & Bioscience

ISSN: 2045-3701

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