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Fig. 2 | Cell & Bioscience

Fig. 2

From: Neutrophil extracellular traps promote thrombogenicity in cerebral venous sinus thrombosis

Fig. 2

Neutrophils form extracellular traps in CVST patients. a–c MPO-DNA, NE-DNA, and citH3-DNA were measured in peripheral blood plasma from healthy subjects (n = 35) and CVST patients (n = 37). NET markers in peripheral venous blood samples from CVST patients were significantly higher than those from healthy subjects. d Flow cytometry was used to examine NET-producing neutrophils (MPO+/citH3+Neut) in samples from healthy controls (n = 32) and CVST patients (n = 37). e–g NET markers were measured in peripheral blood plasma (n = 17) and the venous sinus thrombus site from the same patients (n = 17). h The rate of NET-releasing cells from CVST peripheral blood and CVST venous sinus thrombus site from the same patients(n = 17). i–l Neutrophils isolated from healthy people (n = 10) and CVST patients (peripheral blood plasma and the venous sinus thrombus site, n = 10) were stained with MPO (green) and citH3 (red) and observed by confocal microscopy. Statistics: Unpaired t test with Welch ‘correction (a); Mann–Whitney (b, d); Wilcoxon t test c, g, h; paired t test (a, e, f); Ordinary one-way ANOVA (i). The inset scale bars in E–G are 40 μm. **P < 0.01 and ****P < 0.0001. Neut, Neutrophils

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