Table 3 Overview of mechanisms and animal studies of circRNAs in pancreatic cancer

1

ciRS-7

chrX:q27.1

miR-7

EGFR

STAT3

Onco

30,898,507

2

0000284

chr11:33,307,958–33,309,057

miR-124

IL-6

JAK-STAT3

+

Onco

29,255,366

3

0005273

chr8:141,710,989–141,716,304

KLF12

Onco

33,275,224

4

chr12:74,678,804–74,700,449

chr12:74,678,804–74,700,449

Cyto

none

Onco

32,879,441

5

0001649

chr6:146,209,155–146,216,113

Suppr

29,969,694

6

ASH2L

Cyto (mainly) and nucl

miR-34a

Notch1

EMT; VEGF

+

+

Onco

31,718,694

7

0001460

chr4:178,274,461–178,281,831

Cyto

miR-432-5p

ADAR1

GLI1 (A to I RNA-editing)-EMT/CCND; negative regulation of circNEIL3

+

+

Onco

33,750,389

8

0013912

chr1:145,601,529–145,601,852

Cyto

miR-7-5p

EMT

+

Onco

32,884,344

9

0050102

chr19:18,459,757–18,466,821

Cyto

miR-1182

NPSR1

+

onco

33,289,016

10

0000662

chr16:398,402–398,484

Cyto

miR-361-3p

BTG2

+

Suppr

33,425,718

11

0000677

chr16:16,101,672–16,162,159

Onco

33,413,045

12

0007534

chr17:61,869,771–61,877,977

miR‐625/892b

Bcl2/Bax; MMP2

+

Onco

30,382,592

13

0001946

chrX:q27.1

miR-432-5p

E2F3

+

Onco

33,593,338

14

0006215

chr3:27,478,878–27,490,288

miR-378-3p

SERPINA4

Onco

29,930,719

15

0060055

chr20:33,866,724–33,872,064

miR-557

SLC7A11

PI3K/AKT

+

Onco

33,469,368

16

0066147

chr3:52,960,046–52,962,357

Cyto

miR-330-5p

PAK1

EMT

+

+

Onco

32,855,541

17

0071036

chr4:143,324,090–143,326,477

cyto (mainly) and nucl

miR-489

+

Onco

33,507,122

18

0099999

chr13:20,633,586–20,638,685

miR-335-5p

JMJD2C

+

Onco

30,537,731

19

IARS

miR-122

RhOA

ZO1; F-actin

+

+

Onco

30,064,461

20

0036627

chr15:85,656,607–85,669,605

Cyto (mainly) and nucl

miR-338

MACC1

MET

+

+

Onco

29,709,702

21

ADAM9

miR-217

PRSS3

ERK/VEGF

+

Onco

31,810,373

22

0000069

chr1:47,745,912–47,748,131

Cyto

miR-144

STIL

+

Onco

33,324,055

23

0009065

chr16:14,738,130–14,738,466

Cyto

miR-34b-5p

MET

AKT

+

+

Onco

32,375,768

24

0043278

chr17:35,797,838–35,800,763

Cyto

miR-455-3p

CD80

cytokines

+

Onco

33,505,218

25

0075829

chr6:22,020,567–22,056,919

Cyto

miR-1287-5p

LAMTOR3

ERK/AKT

+

+

Onco

33,184,989

26

chr7:154,954,255–154,998,784

chr7:154,954,255–154,998,784

miR-4459

KIAA0513

+

Onco

33,042,405

27

LDLRAD3

miR-137-3p

PTN

+

Onco

31,521,692

28

0001013

chr2:61,339,656–61,345,251

Cyto

miR-145

KLF5

MMP; VEGF

+

Onco

33,563,550

29

0001568

chr6:349,113–349,256

Cyto (mainly) and nucl

miR-377

HOXC6

PCNA; VEGF; MMP; caspase3

+

Onco

32,193,152

30

0000979

chr2:19,042,277–19,042,456

Cyto

miR-223

SLC4A4

EMT; MMP; VEGF

+

Suppr

32,878,470

31

0086375

chr9:14,146,687–14,155,892

Cyto

miR-486-5p

PIK3R1

PI3K/VEGF

+

+

Suppr

32,366,257

32

03955

miR-3662

HIF-1a

+

Onco

33,864,618

33

0007334

chr2:9,083,315–9,098,771

Cyto

miR-433-3p

GOT1

+

Onco

33,832,516

34

0000977

chr2:10,784,445–10,808,849

miR-153

HIF-1a; ADAM10

Onco

31,402,756

35

0007367

chr9:33,948,371–33,956,144

miR-494

CXCR4/ZEB1

Onco

31,584,877

36

0002130

chr19:6,702,137–6,702,590

miR-4482-3p

NBN

Onco

32,727,565

37

0092314

chr22:20,113,099–20,113,439

Cyto

miR-761

S100P

AKT/EMT

+

Onco

33,842,379

38

0005397

chr17:30,500,849–30,503,232

Cyto

miR-26b-3p/125a-3p/330-5p/382-5p

MAPK; Wnt; Ras

Onco

30,444,423

39

0007334

chr2:9,083,315–9,098,771

miR-144-3p/miR-577

MMP7; COL1A1

Onco

31,428,151

40

0030235

chr13:49,075,877–49,077,050

miR-1253/miR-1294

Onco

30,591,218

41

0000816

chr17:80,521,229–80,526,077

Cyto

miR-942

ANK1; GDNF; PAX6

YBX1; hnRNPK

NUF2; PDXK

+

+

Onco

32,217,695

42

0006988

chr11:36,248,634–36,248,980

Onco

29,307,994

43

chr14:101,402,109–101,464,448

chr14:101,402,109–101,464,448

miR-145-5p

Onco

29,922,161

44

chr4:52,729,603–52,780,244

chr4:52,729,603–52,780,244

miR-145-5p

Onco

29,922,161

45

0000284

chr11:33,307,958–33,309,057

miR-330-5p

RASSF1

EMT

+

Onco

32,104,074

46

101672/004077/003251

Onco

29,781,033

47

101543/002747/000926

Suppr

29,781,033