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Table 2 Overview of cellular functions of circRNAs in pancreatic cancer

From: Biological functions, mechanisms, and clinical significance of circular RNA in pancreatic cancer: a promising rising star

No

Circ

Host gene

Vitro Functions

Specimen

Expression

Reference

Prolife

Cycle

Apopt

Migra

Invas

Angio

Other

1

ciRS7

CDR1as

+

   

+

  

BXPC3/PANC1

Up

30,898,507

2

0000284

HIPK3

+

      

BXPC3

Up

29,255,366

3

0005273

PTK2

+

  

+

   

ASPC1/CFPAC1

Up

33,275,224

4

chr12:7,467,880,474,700,449

 

+

      

BXPC3

Up

32,879,441

5

0001649

SHPRH

+

 

+

    

BXPC3/PANC1

Down

29,969,694

6

ASH2L

ASH2L

+

+

 

+

+

+

 

CAPAN1/ASPC1

Up

31,718,694

7

0001460

NEIL3

+

+

 

+

+

  

CFPAC1/MIAPACA2

Up

33,750,389

8

0013912

POLR3C

+

+

+

+

+

  

ASPC1/PANC1

Up

32,884,344

9

0050102

PGPEP1

+

+

+

+

+

  

CFPAC1/PANC1

Up

33,289,016

10

0000662

AXIN1

+

+

+

+

+

  

ASPC1

Down

33,425,718

11

0000677

ABCC1

+

 

+

+

+

  

ASPC1/BXPC3

Up

33,413,045

12

0007534

DDX42

+

 

+

+

   

PANC1/SW1990

Up

30,382,592

13

0001946

CDR1as

+

 

+

+

+

  

ASPC1/PANC1

Up

33,593,338

14

0006215

SLC4A7

+

 

+

+

   

PANC1

Up

29,930,719

15

0060055

EIF6

+

 

+

+

+

  

HS766T/SW1990

Up

33,469,368

16

0066147

SFMBT1

+

 

+

+

+

  

BXPC3/PANC1

Up

32,855,541

17

0071036

INPP4B

+

 

+

 

+

  

ASPC1/PANC1

Up

33,507,122

18

0099999

ZMYM2

+

 

+

 

+

  

CFPAC1/PANC1

Up

30,537,731

19

IARS

IARS

      

Endothelial permeability

Exo-HUVEC/ASPC1/HS766T/HS766T-L2

Up

30,064,461

20

0036627

PDE8A

+

  

+

+

+

Scatteration

BXPC3/CAPAN2/Exo-HS766T

Up

29,709,702

21

ADAM9

ADAM9

+

  

+

+

  

CAPAN1/MIAPACA2

Up

31,810,373

22

0000069

STIL

+

+

+

+

+

  

MIAPACA2/SW1990; Exo-HPDE/SW1990

Up

33,324,055

23

0009065

BFAR

+

  

+

+

  

BXPC3/PANC1

Up

32,375,768

24

0043278

TADA2A

+

  

+

+

  

PANC1/SW1990

Up

33,505,218

25

0075829

CASC15

+

  

+

+

  

BXPC3/SW1990

Up

33,184,989

26

chr7:154,954,255,154,998,784

 

+

  

+

+

  

PANC1 + NAPSC/CAPSC

Up

33,042,405

27

LDLRAD3

LDLRAD3

+

  

+

+

  

PANC1/SW1990

Up

31,521,692

28

0001013

KIAA1841

+

  

+

+

+

 

ASPC1/PANC1

Up

33,563,550

29

0001568

DUSP22

+

+

+

 

+

+

 

BXPC3/CAPAN2

Up

32,193,152

30

0000979

TCONS_00003590

+

  

+

+

+

 

PANC1

Down

32,878,470

31

0086375

NFIB

   

+

 

+

 

CAPAN2/PANC1

Down

32,366,257

32

circ 03955

 

+

 

+

   

Glycolysis

BXPC3/PANC1

Up

33,864,618

33

0007334

MBOAT2

+

 

+

+

+

 

Glutamine metabolism

PANC1/SW1990

Up

33,832,516

34

0000977

NOL10

      

Inhibition of NK cells under hypoxia

PANC1/NK cell

Induced by hypoxiain

31,402,756

35

0007367

UBAP2

      

Immune infiltration

GSE69362 and GSE79634

Up

31,584,877

36

0002130

C3

       

PANC1/SW1990; PDX tumor

Up

32,727,565

37

0092314

RANBP1

+

   

+

 

CSC

ASPC1/PACA2

Up

33,842,379

38

0005397

RHOT1

+

  

+

+

  

CAPAN2/PANC1

Up

30,444,423

39

0007334

MBOAT2

   

+

   

PANC1

 

31,428,151

40

0030235

RCBTB2

+

 

+

+

+

  

PANC1/SW1990

Up

30,591,218

41

0000816

FOXK2

+

+

+

+

+

  

CFPAC1/PANC1

Up

32,217,695

42

0006988

LDLRAD3

       

ASPC1/CAPAN2/HPCY5/HPDE6C7/PANC1/SW1990

Up

29,307,994

43

chr14:101,402,109,101,464,448

SNHG23

  

+

   

GEM-resistance

PANC1-GEM

Up

29,922,161

44

chr4:5,272,960,352,780,244

DCUN1D4

  

+

   

GEM-resistance

PANC1-GEM

Up

29,922,161

45

0000284

HIPK3

+

 

+

+

+

 

GEM-resistance

PANC1/SW1990-GEM

Up

32,104,074

46

101672/004077/003251

       

GEM-resistance

SW1990-GEM

Up

29,781,033

47

101543/002747/000926

       

GEM-resistance

SW1990-GEM

Down

29,781,033

  1. Prolife: Proliferation; Cycle: Cell cycle; Apopt: Apoptosis; Migra: Migration; Invas: Invasion; Angio: Angiogenesis; CSC: Cancer Stem Cell; GEM: Gemcitabine