Table 1 Overview of circRNAs identified by microarrays and RNA sequencing in pancreatic cancer
No | Sample | Detection | Treatment | GEO | Total circRNAs | Cut-off | CircRNA differently expressed | Reference |
|---|---|---|---|---|---|---|---|---|
1 | 6 PC tissues and 6 paired adjacent nontumor tissues | Microarray |  | GSE69362 | 5396 | Fold change ≥ 1.5 and p < 0.05 | 351 (209 upregulated, 142 downregulated) | 27,997,903 |
2 | 20 PC tissues and 20 paired adjacent nontumor tissues | Microarray | Rnase R | GSE79634 |  | Fold change ≥ 2.0 and p < 0.05 | 289 (128 upregulated, 161 downregulated) | 29,620,241 |
3 | 4 PC tissues and 4 normal pancreatic tissues | Microarray | Rnase R |  | 11,471 | Fold change > 1.5 and p < 0.05 | 193 (120 upregulated, 73 downregulated) | 33,507,122 |
4 | 5 PC tissues and 5 normal pancreatic tissues | Microarray |  |  |  | Fold change > 2 and p < 0.05 |  | 33,593,338 |
5 | 5 PC tissues and 5 paired adjacent nontumor tissues | RNA sequencing | rRNA-depleted and Rnase R |  | 28,374 | Fold change ≥ 2.0 and p < 0.05 | 278 (173 upregulated, 105 downregulated) | 31,428,151 |
6 | 5 PC tissues and 5 paired adjacent nontumor tissues | RNA sequencing |  | GSE136569 |  | Fold change < 0.4 and p < 0.05 | 13 downregulated | 32,366,257 |
7 | 2 PC tissues and 2 normal pancreatic tissues | RNA sequencing | Rnase R |  | 58,050 | false discovery rate < 0.05 |  | 32,879,441 |
8 | 3 PC tissues and 3 normal pancreatic tissues | RNA sequencing | Rnase R | PRJNA695439 |  | Fold change > 1 and p < 0.05 | 203 (79 upregulated, 124 downregulated) | 33,750,389 |
9 | Exosomes of 8 PC plasma and 8 healthy volunteers’ plasma | RNA sequencing | rRNA-depleted and Rnase R |  |  | Fold change ≥ 2.0 and p ≤ 0.05 | 453 (274 upregulated, 179 downregulated) | 31,605,569 |
10 | SW1990 and SW1990-GEM resistant | Microarray | Rnase R |  |  | Fold change ≥ 2.0 and p < 0.05 | 81 (26 upregulated, 55 downregulated) | 29,781,033 |
11 | PANC1 and PANC1-GEM resistant | RNA sequencing |  | GSE1105801 |  | Fold change ≥ 2.0 and p < 0.05 | 126 (68 upregulated, 58 downregulated) | 29,922,161 |
12 | PC cells with or without Ten Gy of X-ray radiation | RNA sequencing | Ribo-Zero rRNA Removal Kits |  | 12,572 | Fold change > 2 and p < 0.05 | 196 (182 upregulated, 14 downregulated) | 32,727,565 |
13 | PANC1 and PANC1-autophagic inhibition | Microarray | Â | Â | 9420 | Â | Â | 30,570,107 |
14 | PANC1 and PANC1-nigericin; SW1990 and SW1990-nigericin | RNA sequencing | remove ribosomal RNA | PRJNA543685 |  | Fold change ≥ 2.0 and p < 0.05 | 183 (141 upregulated, 42 downregulated) | 31,533,620 |
15 | Exosomes of Hs766T and Hs766T-L2 cells | Microarray | RNase R | Â | Â | Â | Â | 29,709,702 |
16 | Stellate cells from 5 PC and 5 normal tissues | RNA sequencing |  |  |  | Fold change ≥ 2.0 and p ≤ 0.05 | 841 (388 upregulated, 453 downregulated) | 33,042,405 |