Fig. 7
From: IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression
C3aR blockade prevented C3 tagging with synaptic proteins in the prefrontal cortex of CUMS mice. Representative photographs of PSD95(red)/C3(green)/DAPI(blue) (A). C3aR blockade decreased the ratio of C3 area (B) and the ratio of PSD95 colocalized with C3 (C). Representative photographs of Synaptophysin(red)/C3(green)/DAPI(blue) (D). C3aR blockade decreased the ratio of C3 area (E) and the ratio of synaptophysin colocalized with C3 (F). Data were obtained from 5 samples per group. ##P < 0.01 versus the Control-vehicle group. **P < 0.01 versus the CUMS-vehicle group