Fig. 3
From: IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression
LPS caused the elevation of C3 and its receptor C3aR in the prefrontal cortex after 6 h and 24 h. The effects of LPS on crossing number (A), rearing number (B), sucrose preference (C) and immobility time (D) in mice. LPS enhanced C3 (E) and C3aR (F) expression. Representative photographs of C3(green) (G) and the statistical results (H). Representative photographs of Iba1(green)/C3aR(red)/DAPI(blue) (I). LPS increased microglial activation (J) and C3aR (K) expression. Data were obtained from 5–10 samples per group. #P < 0.05 and ##P < 0.01 versus the Control-vehicle group