Fig. 10
From: IL-1R/C3aR signaling regulates synaptic pruning in the prefrontal cortex of depression
Schematic diagram shows that the activation of astrocyte IL-1R/NF-κB/C3 signaling and microglial C3aR/APT2/DHHC7 palmitoylation mediates the pathophysiology of depression. Complement C3 is over-expressed by astrocyte IL-1R/NF-κB/C3 pathway in response to stress. Astrocyte-neuron crosstalk mediates through the release of complement C3 from astrocyte and the localization of C3 with neurons. Astrocyte-microglia crosstalk mediates through C3-C3aR chemotaxis. Microglia-neuron crosstalk acts through APT2/DHHC7 mediated C3aR-STAT3 activation and synaptic pruning