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Table 2 Selection of the significant metabolites

From: Metabolomics of blood reveals age-dependent pathways in Parkinson’s Disease

Type

Name

fi

C

Name

fi

C

Name

fi

C

Acylcarnitines

Carnitine

 

0.9

Tiglyl-

 

0.0

Hexadecanoyl

3

0.9*

Acetyl-

3

0.9*

Pimelyl-

 

1.1*

Hexadecenoyl

3

0.8*

Butenyl-

 

1.2*

Dodecenoyl-

 

0.5*

Octadecenoyl

3

0.8*

Methylmalonyl

 

2.4

Tetradecenoyl

1

0.8*

   

Alkaloids

Trigonellyne

 

1.1

      

Amine oxids

Trimethylamine N-oxide

 

1.7*

      

Amino acid related

Asymmetric Dimethylargin

 

0.9

Citrulline

 

1.1

Kynurenine

 

0.8

Methionine-sulfoxide

2

0.8*

1-Methylhistidine

 

0.8

   

Amino acids

Cysteine

 

1.2

Glutamine

 

1.1

Glutamic Acid

2

0.8

Threonine

 

1.2*

      

Bile acids

Cholic acid

 

2.0

Chenodeoxy acid

 

1.9*

Deoxycholic acid

 

1.4

Glycolithochol acid*

 

1.4

Glycolithochol Acid sulfate

 

1.2*

   

Biogenic Amines

Gamma-amino butyracid

 

0.8*

Putrescine

 

1.6*

Serotonin

 

0.2

Ceramides

d16:1/24:0

 

1.3

d18:1/20:0

1

1.2

d18:1/26:1

 

1.3*

d18:1/16:0

1

1.1

d18:1/24:0

 

1.2

d18:2/18:0

1

1.1

d18:1/18:0

1

1.2

d18:1/24:1

1

1.3*

d18:2/20:0

 

1.2*

d18:0/26:1OH

 

10.3

d18:1/24:4

 

1.2

d18:2/24:0

1

1.2

d18:1/20:0 (OH)

 

1.2

d18:1/22:0

1

1.2

d18:2/24:1

1

1.2

Cholesteryl esters

16:1

 

0.9

22:5

 

1.1*

20:4

1

0.9

17:1

 

1.1

20:0

2

0.7*

22:1

2

0.8*

18:1

1

0.9*

20:1

2

0.7*

22:2

2

0.7*

Cresols

p-Cresol sulfate

 

1.2

      

Diglycerides

16:1_18:0

 

0.8

16:1_18:1

 

0.9

18:2_18:4

 

0.7

16:0_18:1

 

0.9

17:0_18:1

 

0.9

18:1_18:1

2

0.9

16:0_20:3

 

0.8*

16:1_20:0

 

4.6*

18:2_18:2

 

1.4*

Dihexosyl ceramides

d18:1/14:0

 

1.1

d18:1/20:0

1

1.2

d18:0/26:1

 

1.2

d18:1/16:0

1

1.2*

d18:1/24:0

1

1.1

   

d18:1/18:0

1

1.2

d18:1/24:1

1

1.1*

   

Fatty acids

Arachnidonic

2

0.6*

Docosahex

3

0.7*

Eicosapent

 

0.7*

Eicosatrienoic

 

0.3*

Myristic

3

0.2*

Eicosenoic

 

0.6*

Octadecadienoate

3

0.8*

      

Hexosyl ceramides

d18:1/24:1

1

1.2*

d18:1/23:0

1

1.1

d18:2/18:0

1

1.2

d18:1/18:1

1

1.1

d18:1/26:0

1

1.1

d18:2/23:0

1

1.2

Hormones

Cortisol

 

1.2*

Cortisone

 

0.9

   

Indoles

Indoleacetic acid

 

1.7*

Indolepropionic acid

 

0.7

Indoxylsulfate

 

0.7*

Lyso-phosphatidyl

LysoPC(17:0)

2

1.1*

LysoPC(18:2)

 

1.2*

LysoPC(28:1)

 

0.8*

Phosphatidyl-cholines

aaC34:1

1

1.1

aaC36:3

1

 

aeC32:2

1

1.1

aaC32:0

1

1.1

aaC38:1

1

1.1

aeC34:3

1

1.2

aaC32:2

1

1.2

aaC42:0

1

1,2*

aeC34:2

1

1.2

aaC34:2

2

1.2

aeC30:2

4

0.8*

aeC44:6

2

1.2

aaC34:3

2

1.1

aaC42:1

1

1.2*

aeC36:3

1

1.3

aaC36:2

1

1.1

aeC38:4

1

0.9

aeC38:0

4

1.1

aeC44:4

2

1.2

aeC40:5

2

1.1*

aeC40:2

2

1.2*

aeC42:4

1

1.1*

      

Sphingomyelins

Hydro-SM(14:1)

 

0.9

SM(16:0)

1

1.0*

SM(22:3)

 

0.6

Hydro-SM(16:1)

1

0.9

SM(16:1)

1

0.9

SM(24:0)

 

0.9

Hydro-SM(22:1)

1

0.9

SM(18:0)

1

0.9

SM(24:1)

1

0.9*

Hydro-SM(22:2)

1

0.9

SM(18:1)

1

0.9

SM(26:0)

 

0.9

Hydro-SM(24:1)

1

0.9

SM(20:2)

1

0.9

SM(26:1)

1

0.9*

Triglycerides

(16:0_35:3)

0

1.2*

(18:2_31:0)

0

1.2*

(18:2_35:1)

0

1.3*

Trihexosyl ceramides

(d18:1/16:0)

 

1.1*

(d18:1/18:0)

 

1.1*

(d18:1/24:1)

 

1.1*

(d18:1/26:1)

 

1.1*

      

Vitamins

Choline

2

0.8*

      
  1. The table contains the association of each element to the respective principal component f1, f2, or f3 (if significant). C indicates the ratio between the concentration of the metabolite in PD and HC: values higher or lower than 1.0 indicates, respectively, elevated or decreased metabolite level in PD. The asterisk (*) indicates parameters validated with  OPLS. Parameters in bold are additionally cross-validated with PCA. The complete list of Triglycerides is in the Additional file 1: Table S2. We show here only these Triglycerides cross-validated with PCA