Fig. 2
From: Metabolomics of blood reveals age-dependent pathways in Parkinson’s Disease
The OPLS model with 3 orthogonal and 1 predictive components can distinguish between PD and HC with an AUC in the range (0.97, 1.0) at a 95% confidence level (A). The principal component analysis applied to the significant metabolic parameters with VIP > 1 identifies 5 components expressing up to 80% of the total variance. In particular, f0,1,4 does not exhibit any age dependence (B), f2 exhibits a age correlation only for PD patients (C) and f3 exhibits a age correlation only for HC subjects (D). Sphingomyelin (E), Choline (F) and Hexadecanoyl-carnitine (G) are among the main contributions to the three principal components