Fig. 1
From: Metabolomics of blood reveals age-dependent pathways in Parkinson’s Disease
Data driven modeling for the discrimination between PD and HC subjects. The PLS model exhibits a good separation between the two categories of subjects (A) and its goodness is apparently confirmed by a resampling with replacement validation technique (B). However, we observe a non-negligible overfitting (C). With respect to PLS, the OPLS model exhibits a better separation between the two classes (D), confirmed with a P-value of 9 × 10–4 (E) and absence of overfitting (F)