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Fig. 6 | Cell & Bioscience

Fig. 6

From: H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition

Fig. 6

Working model. A Working model for JUN induced PST. In embryonic stem cells, opened chromatin marked by H3K27ac are occupied by SS18/BAF and pluripotent transcriptional factors. The induction of cJUN for 4 h can trigger deposition of H3K27ac in cJUN/AP-1 binding sites, which are further recognized by SS18/BAF, leading the opening of the target chromatin and activation of somatic genes. The green asterisk represents H3K27ac

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