Skip to main content
Fig. 3 | Cell & Bioscience

Fig. 3

From: Targeting tumor-associated macrophages for cancer treatment

Fig. 3

Relations between TAMs and PD-1/PD-L1 checkpoint in immune suppressive TME. a TAMs promote expression of CCR6+ Tregs by secreting CCL20, which accelerates the formation of immunosuppressive TME. Moreover, the PD-L1 of TAMs binds with the PD-1 of CD8 T cells, which inhibits ability of CD8 T cells to recognize cancer cells. b Tumor cells enhance the recruitment and polarization of M2-TAMs through the CCL2-CCR2 axis. Meanwhile, TAMs in turn facilitate the expression of PD-L1 in tumor cells, which forms a positive feedback loop and leads to tumor immune escape. c PD-L1 upregulation in TAMs enhances the polarization of TAMs from M1-like TAMs to M2-like TAMs. PD-1 programmed cell death 1(PD-1), PD-L1 PD ligand 1, CCL2 chemokine (C-C motif) ligand 2, CCR2 chemokine receptors type 2, Tregs regulatory T cells

Back to article page