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Table 4 Phosphorylation of SIRT family proteins and its effect on the enzymatic activity

From: The phosphorylation to acetylation/methylation cascade in transcriptional regulation: how kinases regulate transcriptional activities of DNA/histone-modifying enzymes

Isoforms of KMTs

Target residues

Kinases

Functional regulation upon phosphorylation

Involved in diseases and signaling pathways

References

SIRT1

Ser27

CaMKKβ

Stabilization

Inflammation

[194]

PKC

DNA binding

Oligodendrocytes survival

[195]

JNK1

Activation of enzymatic activity

Stress protection pathway

[196]

Ser47

CaMKKβ

Stabilization

Inflammation

[194]

CDK5

Stabilization

Diabetic Nephropathy

[197]

p38 MAPK

Stabilization

Age-related diseases

[198]

JNK/SAPK

JNK1

Activation of enzymatic activity

Obesity

[199]

mTOR

Inhibition of enzymatic activity

DNA damage

[185]

Ser164

CK2

Inhibition of its nuclear localization

Obesity

[200]

Ser280

JAK1

Enhance of its interaction with STAT3

JAK1-STAT3 pathway

[201]

Ser301

Thr344

AMPK

Inhibition of enzymatic activity

Liver cancer

[202]

Thr522

DYRK1A/DYRK3

Activation of enzymatic activity

Cellular stress response

[203]

Thr530

DYRK2

DNA binding

 

[204]

AMPK

Enhance of its interaction with PABP1

Eukaryotic Poly(A)RNA Transport

[205]

Ser615

LKB1

Enhance of intramolecular interactions in Sirt1

Mitochondrial metabolism

[206]

Ser649

CK2

Activation of enzymatic activity

Alzheimer’s disease

[207]

Ser659

CK2

Enhance of its interaction with HIC1

DNA damage

[208]

Ser661

CK2

Ser669

LKB1

Enhance of intramolecular interactions in Sirt1

Mitochondrial metabolism

[206]

Ser682

HIPK2

Inhibition of enzymatic activity

DNA damage

[209]

Thr719

AMPK

Enhance of its interaction with PABP1

Eukaryotic Poly(A)RNA Transport

[205]

Ser732

LKB1

Enhance of intramolecular interactions in Sirt1

Mitochondrial metabolism

[206]

SIRT2

Tyr104

c-SRC

Inhibition of enzymatic activity

 

[210]

Ser327

GSK3β

Inhibition of enzymatic activity

Parkinson’s disease

[186]

Ser335

Ser331

GSK3β

CDK2

Inhibition of enzymatic activity

Cell cycle

[187]

Ser368

CDK1

DNA binding

Cell cycle

[211]

CDK5

Inhibition of enzymatic activity

Cell cycle

[188]

Ser372

Ser473

CK2

Inhibition of enzymatic activity

Dietary restriction (DR)-mediated lifespan extension

[189]

SIRT6

Ser10

JNK

DNA binding

DNA damage

[192]

Ser338

AKT

Degradation

Breast cancer

[190]

CSNK2A1

DNA binding

Osteosarcoma

[212]

Thr294

PKC

Enrichment on chromatin

Colon Cancer

[191]