Isoforms of KMTs | Target residues | Kinases | Functional regulation upon phosphorylation | Involved in diseases and signaling pathways | References |
---|---|---|---|---|---|
SIRT1 | Ser27 | CaMKKβ | Stabilization | Inflammation | [194] |
PKC | DNA binding | Oligodendrocytes survival | [195] | ||
JNK1 | Activation of enzymatic activity | Stress protection pathway | [196] | ||
Ser47 | CaMKKβ | Stabilization | Inflammation | [194] | |
CDK5 | Stabilization | Diabetic Nephropathy | [197] | ||
p38 MAPK | Stabilization | Age-related diseases | [198] | ||
JNK/SAPK | |||||
JNK1 | Activation of enzymatic activity | Obesity | [199] | ||
mTOR | Inhibition of enzymatic activity | DNA damage | [185] | ||
Ser164 | CK2 | Inhibition of its nuclear localization | Obesity | [200] | |
Ser280 | JAK1 | Enhance of its interaction with STAT3 | JAK1-STAT3 pathway | [201] | |
Ser301 | |||||
Thr344 | AMPK | Inhibition of enzymatic activity | Liver cancer | [202] | |
Thr522 | DYRK1A/DYRK3 | Activation of enzymatic activity | Cellular stress response | [203] | |
Thr530 | DYRK2 | DNA binding | Â | [204] | |
AMPK | Enhance of its interaction with PABP1 | Eukaryotic Poly(A)RNA Transport | [205] | ||
Ser615 | LKB1 | Enhance of intramolecular interactions in Sirt1 | Mitochondrial metabolism | [206] | |
Ser649 | CK2 | Activation of enzymatic activity | Alzheimer’s disease | [207] | |
Ser659 | CK2 | Enhance of its interaction with HIC1 | DNA damage | [208] | |
Ser661 | CK2 | ||||
Ser669 | LKB1 | Enhance of intramolecular interactions in Sirt1 | Mitochondrial metabolism | [206] | |
Ser682 | HIPK2 | Inhibition of enzymatic activity | DNA damage | [209] | |
Thr719 | AMPK | Enhance of its interaction with PABP1 | Eukaryotic Poly(A)RNA Transport | [205] | |
Ser732 | LKB1 | Enhance of intramolecular interactions in Sirt1 | Mitochondrial metabolism | [206] | |
SIRT2 | Tyr104 | c-SRC | Inhibition of enzymatic activity | Â | [210] |
Ser327 | GSK3β | Inhibition of enzymatic activity | Parkinson’s disease | [186] | |
Ser335 | |||||
Ser331 | GSK3β | ||||
CDK2 | Inhibition of enzymatic activity | Cell cycle | [187] | ||
Ser368 | CDK1 | DNA binding | Cell cycle | [211] | |
CDK5 | Inhibition of enzymatic activity | Cell cycle | [188] | ||
Ser372 | |||||
Ser473 | CK2 | Inhibition of enzymatic activity | Dietary restriction (DR)-mediated lifespan extension | [189] | |
SIRT6 | Ser10 | JNK | DNA binding | DNA damage | [192] |
Ser338 | AKT | Degradation | Breast cancer | [190] | |
CSNK2A1 | DNA binding | Osteosarcoma | [212] | ||
Thr294 | PKC | Enrichment on chromatin | Colon Cancer | [191] |