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Table 2 Phosphorylation of histone acetyltransferases and its effect on the enzymatic activity

From: The phosphorylation to acetylation/methylation cascade in transcriptional regulation: how kinases regulate transcriptional activities of DNA/histone-modifying enzymes

Isoforms of KMTs

Synonyms

Target residues

Kinases

Functional regulation upon phosphorylation

Involved in diseases and signaling pathways

References

KAT1

HAT1

Ser190

AMPK

Activation of enzymatic activity

Mitochondrial biogenesis and function

[112]

KAT2A

GCN5

Ser275

PKA

Activation of enzymatic activity

Hepatic glucose metabolism

[104]

KAT2B

PCAF

Unknown

AKT

Activation of enzymatic activity

Esophageal squamous cell carcinoma

[106]

KAT3A

CBP

Ser436

PKC

Disruption of its binding to chromatin

Hippocampal neurogenesis

[94]

KAT3B

P300

Ser12

MAPK

Activation of enzymatic activity

Cancer-Induced Muscle Wasting

[118]

Ser89

AMPK

Inhibition of enzymatic activity

Endothelial cell inflammation

[120]

PKC

Disruption of its binding to chromatin

Cell growth and differentiation

[111]

SIK2

Disruption of its interaction with PPARα

Hepatic lipid homeostasis

[112]

Ser106

ATM

Stabilization of NBS1

DNA damage

[110]

Ser1038

CDK1

Degradation

Lung cancer

[113]

Ser2039

Ser1834

AKT

Activation of enzymatic activity

Cell cycle

[105]

Ser1849

Unknown

Activation of enzymatic activity

 

[121]

Thr1851

Thr1854

Thr1857

Thr2279

Ser2271

mTOR

Activation of enzymatic activity

Autophagy and Lipogenesis

[108]

Ser2279

Ser2291

Ser2315

Ser2279

ERK2

Activation of enzymatic activity; Enhance of its interaction with SP1

Signal-regulated kinase 1 and 2 (ERK1/2) signaling

[109]

Ser2315

Ser2366

KAT5

TIP60

Ser86

GSK3

Activation of enzymatic activity

Apoptosis; PI3K signaling

[122]

Ser90

CDK9

Enhance of its binding to chromatin

Cell proliferation

[117]

Cyclin B/CDC2

Activation of enzymatic activity

Cell cycle

[123]

KAT7

HBO1

Ser50

ATR

Enhance of its binding to chromatin

Nucleotide excision repair

[124]

Ser53

Ser57

PIK1

Enhance of its binding to chromatin

Cell cycle

[116]

Ser85

CDK1

Ser88

CDK1

Cyclin E/CDK2

Enhance of its binding to chromatin

Cell cycle

[125]

Thr97

PKD1

Stabilization

Cell proliferation

[119]

Thr331

KAT8

MOF

Thr392

ATM

Disruption of its interaction with 53BP1

Double-strand break repair

[126]

KAT13A

SRC1

Thr426

CDKs

Enhance of its interaction with PR

Breast cancer

[127]

Ser22

Cyclin A2/CDK2

Ser395

Ser569

Ser1033

Thr1179

Thr1185

Thr1426

CDK1/2