Isoforms of KMTs | Synonyms | Target residues | Kinases | Functional regulation upon phosphorylation | Involved in diseases and signaling pathways | References |
---|---|---|---|---|---|---|
KAT1 | HAT1 | Ser190 | AMPK | Activation of enzymatic activity | Mitochondrial biogenesis and function | [112] |
KAT2A | GCN5 | Ser275 | PKA | Activation of enzymatic activity | Hepatic glucose metabolism | [104] |
KAT2B | PCAF | Unknown | AKT | Activation of enzymatic activity | Esophageal squamous cell carcinoma | [106] |
KAT3A | CBP | Ser436 | PKC | Disruption of its binding to chromatin | Hippocampal neurogenesis | [94] |
KAT3B | P300 | Ser12 | MAPK | Activation of enzymatic activity | Cancer-Induced Muscle Wasting | [118] |
Ser89 | AMPK | Inhibition of enzymatic activity | Endothelial cell inflammation | [120] | ||
PKC | Disruption of its binding to chromatin | Cell growth and differentiation | [111] | |||
SIK2 | Disruption of its interaction with PPARα | Hepatic lipid homeostasis | [112] | |||
Ser106 | ATM | Stabilization of NBS1 | DNA damage | [110] | ||
Ser1038 | CDK1 | Degradation | Lung cancer | [113] | ||
Ser2039 | ||||||
Ser1834 | AKT | Activation of enzymatic activity | Cell cycle | [105] | ||
Ser1849 | Unknown | Activation of enzymatic activity | Â | [121] | ||
Thr1851 | ||||||
Thr1854 | ||||||
Thr1857 | ||||||
Thr2279 | ||||||
Ser2271 | mTOR | Activation of enzymatic activity | Autophagy and Lipogenesis | [108] | ||
Ser2279 | ||||||
Ser2291 | ||||||
Ser2315 | ||||||
Ser2279 | ERK2 | Activation of enzymatic activity; Enhance of its interaction with SP1 | Signal-regulated kinase 1 and 2 (ERK1/2) signaling | [109] | ||
Ser2315 | ||||||
Ser2366 | ||||||
KAT5 | TIP60 | Ser86 | GSK3 | Activation of enzymatic activity | Apoptosis; PI3K signaling | [122] |
Ser90 | CDK9 | Enhance of its binding to chromatin | Cell proliferation | [117] | ||
Cyclin B/CDC2 | Activation of enzymatic activity | Cell cycle | [123] | |||
KAT7 | HBO1 | Ser50 | ATR | Enhance of its binding to chromatin | Nucleotide excision repair | [124] |
Ser53 | ||||||
Ser57 | PIK1 | Enhance of its binding to chromatin | Cell cycle | [116] | ||
Ser85 | CDK1 | |||||
Ser88 | CDK1 | |||||
Cyclin E/CDK2 | Enhance of its binding to chromatin | Cell cycle | [125] | |||
Thr97 | PKD1 | Stabilization | Cell proliferation | [119] | ||
Thr331 | ||||||
KAT8 | MOF | Thr392 | ATM | Disruption of its interaction with 53BP1 | Double-strand break repair | [126] |
KAT13A | SRC1 | Thr426 | CDKs | Enhance of its interaction with PR | Breast cancer | [127] |
Ser22 | Cyclin A2/CDK2 | |||||
Ser395 | ||||||
Ser569 | ||||||
Ser1033 | ||||||
Thr1179 | ||||||
Thr1185 | ||||||
Thr1426 | CDK1/2 |