Skip to main content
Fig. 7 | Cell & Bioscience

Fig. 7

From: Mxc, a Drosophila homolog of mental retardation-associated gene NPAT, maintains neural stem cell fate

Fig. 7

Diagram depicting the mechanisms of neuronal and locomotion defects caused by mxc knockdown in Drosophila larval brain NBs. A In wt, Mxc is required for HLB assembly and histone transcription, which maintains genomic stability and CNS development. B The absence of Mxc impairs HLB assembly which in turn reduces the transcription levels of canonical histone genes and induces DSBs. NB proliferation and GMC differentiation is affected under this stress, resulting in neuronal and locomotion defects in adult flies. Nuclear Pros is prematurely accumulated in third-instar larval brain NBs to terminate NB cell fate, potentially protecting from NB over-growth. Autophagy is also elevated in mxc knockdown NBs to impede Dpn+ GMC formation

Back to article page