Fig. 7

The molecular mechanism plot for the role of Rbpjl in AP. Rbpjl down-regulates Arid5a expression by binding to the Arid5a promoter region, thus reducing IL-6 expression and STAT3 protein phosphorylation, and STAT3 translocation into nuclei. Further, Rbpjl inhibits activation of the IL-6/STAT3 signaling pathway, and the production of inflammatory factors TNF-α, IL-1β and IL-6, thereby alleviating AP