Fig. 7From: FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusionPyroptosis mediated by the pore-forming protein GSDMD is a necessary step of neuroinflammation and subsequent neuronal apoptosis after SCI. We demonstrated that deficiency of FANCC, a member of the FA gene family, can aggravate microglial pyroptosis and neuronal apoptosis via p38/NLRP3 signaling pathwayBack to article page