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Fig. 1 | Cell & Bioscience

Fig. 1

From: Histone deacetylase 3 facilitates TNFα-mediated NF-κB activation through suppressing CTSB induced RIP1 degradation and is required for host defense against bacterial infection

Fig. 1

Elevated expression of cathepsins in HDAC3 deficient macrophages. A Western blot analysis of HDAC3 in Vector and Hdac3−/− RAW264.7 cells. B Volcano plot for genes significantly changed (≥ 2 fold change, P < 0.05) after HDAC3 knockout. C, D Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis for genes significantly changed (≥ 2 fold change, P < 0.05) after HDAC3 knockout. E Heat map of relative lysosome related mRNA expression. F PCR analysis of Ctsa, Ctsb, Ctsc, Ctsd, Ctse, Ctsf, Ctsg, Ctsh, Ctsk, Ctsl, Ctso, Ctss, Ctsw, Ctsz in Vector and Hdac3−/− RAW264.7 cells. Data are representative of three independent experiments and showed as mean ± SEM. **P < 0.01

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Cell & Bioscience

ISSN: 2045-3701

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