Skip to main content
Fig. 6 | Cell & Bioscience

Fig. 6

From: The two-faced role of ATF2 on cisplatin response in gastric cancer depends on p53 context

Fig. 6

ATF2 was a chemotherapy resistance indicator for GC with dysfunctional p53. A Xenografts tumor size of ATF2 over-expressing group and control group with or without cisplatin treatment in HGC-27 cells. The animals were treated with intraperitoneal (i.p.) injection of cisplatin (3 mg/kg) or PBS when the average tumor volume reached 1500 mm3. Cisplatin was injected once weekly for two weeks. Data were presented as mean ± SEM (n = 5/group). B Xenografts tumor size of AGS over-expressing group and control group without cisplatin administration in AGS cells. C The overall survival of high and low ATF2 GC patients with or without chemotherapy when p53 was mutated. D The overall survival of high and low ATF2 GC patients with or without chemotherapy when p53 was wild type. E Statistical analysis of different p53 splicing variants in GC tissues using TCGA database. The right figure represents the number of exons contained in the p53 splicing variants, data provided by TSVdb database. UC010cne isoform lacked the 1st to 8th exons of p53; UC002-gii isoform lacked the1st to 4th exons of p53; UC002-gij isoform retains the full length of p53. N: normal adjacent noncancerous tissues. T tumor tissues. Paired-Samples t test is used, and *p < 0.05, **p < 0.01. F The model of the biological functions played by ATF2 in p53 mutated or wild type GC cells

Back to article page