Fig. 2

Cell-type deconvolution of the kidney tissues from 9 and 18 weeks post-conception. a The histological structure of the 18 PCW kidney and the proportion of signatures of different scRNA-seq cell types in each ST spot. Each pie chart represents the contribution of scRNA-seq cell types to the transcriptomic signature of each ST spot. Only cell types that contribute at least 10% to the spot signature are shown. Dashed boxes at the same level corresponding to the same histology section location. The junction between the cortex and the medulla is marked with a red line. b Spatial mapping of scRNA-seq cell subsets performed by MIA, and expression localization of marker genes. The red box corresponds to the histology section location selected by the dashed box in (a). c Spatial spots identification for the human embryonic kidneys from 9 post-conception weeks. d The proportion of signatures of different scRNA-seq cell types in each ST spot (up) and the spatial mapping of scRNA-seq cell subsets performed by MIA (down)