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Table 2 Details of the top 10 up/down-regulated genes

From: RNA sequencing profiles reveal dynamic signaling and glucose metabolic features during bone marrow mesenchymal stem cell senescence

Gene Name Chromosome Fold change P value FDR
Up-regulated     
 CILP 8 68.414 3.530E−04 0.017
 FHL1 X 50.450 1.184E−04 0.013
 TGFB3 6 49.868 9.427E−05 0.012
 ACTA2 1 46.407 1.783E−03 0.029
 ITGA8 17 44.424 4.355E−05 0.010
 MYH11 10 43.851 3.185E−04 0.017
 MYOCD 10 30.975 2.123E−04 0.016
 ELN 12 28.741 5.912E−03 0.046
 FAM150A 5 24.827 3.258E−04 0.017
 IL1RL1 9 24.463 1.143E−02 0.062
Down-regulated     
 SFRP1 16 0.008 4.656E−05 0.010
 AKR1C14 17 0.017 5.622E−04 0.020
 CDH2 18 0.018 1.088E−08 5.212E−05
 MT2A 19 0.019 6.261E−05 0.011
 CSCL6 14 0.022 1.357E−02 0.067
 SLC1A3 2 0.025 1.558E−05 0.006
 RBP4 1 0.025 1.860E−03 0.029
 LUM 7 0.026 6.696E−04 0.021
 CCL20 9 0.029 1.638E−03 0.028
 IL1RN 3 0.032 2.500E−04 0.016
  1. FDR the adjusted P value, P value the P value of the F-statistic for gene from young and old MSCs, ACTA2 actin alpha 2, AKR1C14 aldo–keto reductase family 1 member C14, ALKAL1 ALK and LTK ligand 1, CCL20 C–C motif chemokine ligand 20, CDH2 cadherin 2, CILP cartilage intermediate layer protein, CXCL6 C-X-C motif chemokine ligand 6, ELN elastin, FHL1 four and a half LIM domains 1, IL1RL1 interleukin 1 receptor-like 1, IL1RN interleukin 1 receptor antagonist, ITGA8 integrin subunit alpha 8, LUM lumican, RBP4 retinol binding protein 4, MT2A metallothionein 2A, MYH11 myosin heavy chain 11, MYOCD myocardin, SFRP1 secreted frizzled-related protein 1, SLC1A3 solute carrier family 1 member 3, TGFB3 transforming growth factor beta 3