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Table 2 Details of the top 10 up/down-regulated genes

From: RNA sequencing profiles reveal dynamic signaling and glucose metabolic features during bone marrow mesenchymal stem cell senescence

Gene Name

Chromosome

Fold change

P value

FDR

Up-regulated

    

 CILP

8

68.414

3.530E−04

0.017

 FHL1

X

50.450

1.184E−04

0.013

 TGFB3

6

49.868

9.427E−05

0.012

 ACTA2

1

46.407

1.783E−03

0.029

 ITGA8

17

44.424

4.355E−05

0.010

 MYH11

10

43.851

3.185E−04

0.017

 MYOCD

10

30.975

2.123E−04

0.016

 ELN

12

28.741

5.912E−03

0.046

 FAM150A

5

24.827

3.258E−04

0.017

 IL1RL1

9

24.463

1.143E−02

0.062

Down-regulated

    

 SFRP1

16

0.008

4.656E−05

0.010

 AKR1C14

17

0.017

5.622E−04

0.020

 CDH2

18

0.018

1.088E−08

5.212E−05

 MT2A

19

0.019

6.261E−05

0.011

 CSCL6

14

0.022

1.357E−02

0.067

 SLC1A3

2

0.025

1.558E−05

0.006

 RBP4

1

0.025

1.860E−03

0.029

 LUM

7

0.026

6.696E−04

0.021

 CCL20

9

0.029

1.638E−03

0.028

 IL1RN

3

0.032

2.500E−04

0.016

  1. FDR the adjusted P value, P value the P value of the F-statistic for gene from young and old MSCs, ACTA2 actin alpha 2, AKR1C14 aldo–keto reductase family 1 member C14, ALKAL1 ALK and LTK ligand 1, CCL20 C–C motif chemokine ligand 20, CDH2 cadherin 2, CILP cartilage intermediate layer protein, CXCL6 C-X-C motif chemokine ligand 6, ELN elastin, FHL1 four and a half LIM domains 1, IL1RL1 interleukin 1 receptor-like 1, IL1RN interleukin 1 receptor antagonist, ITGA8 integrin subunit alpha 8, LUM lumican, RBP4 retinol binding protein 4, MT2A metallothionein 2A, MYH11 myosin heavy chain 11, MYOCD myocardin, SFRP1 secreted frizzled-related protein 1, SLC1A3 solute carrier family 1 member 3, TGFB3 transforming growth factor beta 3