Fig. 2

Gene expression analysis of MSCs from young and old rats. A Pearson correlation heatmap of mRNAs in MSCs from young and old rats (n = 3). B Principal component analysis (PCA) of the gene changes. C, D The heatmap and scatter plots showing the differential expression profiles of genes between the two study groups and the homogeneity in each group. E Volcano plot of DEGs. The green and red dots in the plot represent the DEGs with statistical significance. The red color represents the up-regulated gene, the green color represents the down-regulated gene, and the black represents the gene with no significant change