Fig. 2
From: Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants
R3P1-E4 suppresses SARS-CoV-2 pseudovirus and authentic virus infection in vitro. A Germline usage comparison of heavy chain and light chain of R3P1-A12, R3P2-A2, R3P1-E4, R3P2-B5, R3P1-B6 and R3P2-G1 mAbs. B Alignment of the heavy chain and light chain variable domain sequence of R3P1-A12, R3P2-A2, R3P1-E4, R3P2-B5, R3P1-B6 and R3P2-G1 mAbs. The sequences in the box are variable region of mAbs. C Antibody competition with hACE2 receptor assay were performed to test the abilities of screened mAbs to competitively bind with RBD protein against hACE2. D The abilities of screened mAbs to neutralize SARS-CoV-2 pseudovirus were examined by pseudovirus neutralization assay. E The abilities of screened mAbs to neutralize SARS-CoV-2 authentic virus were examined by authentic virus neutralization assay