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Fig. 1 | Cell & Bioscience

Fig. 1

From: Rho family GTPase 1 (RND1), a novel regulator of p53, enhances ferroptosis in glioblastoma

Fig. 1

RND1 is downregulated and associates with prognosis in GBM. A Relative RND1 mRNA level in human normal brain (n = 10) and GBM tissues (n = 528) according to the TCGA dataset. B Relative RND1 mRNA level in grade II (n = 226), grade III (n = 244) and grade IV (n = 150) of glioma tissues based on TCGA dataset. C Relative RND1 mRNA expression in the CL (n = 199), ME (n = 166) and PR (n = 163) subtypes of GBM based on TCGA dataset. CL, classical; ME, mesenchymal; PR, proneural. D Western blot analysis of RND1 protein level in clinical human normal brain (n = 4) and GBM (n = 8) tissues. E Relative expression of RND1 protein in normal brain and GBM tissues was quantified. F IHC staining images for RND1 in clinical human normal brain, LGG and GBM tissues. Scale bars, 50 μm. LGG, low grade glioma. G Positive stained area of IHC staining for RND1 was quantified. H Relative RND1 mRNA expression of clinical human normal brain (n = 4), LGG (n = 14) and GBM (n = 41) tissues was quantified. I Kaplan–Meier survival analysis for clinical GBM patients with RND1 expression in tumor tissues. *P < 0.05; **P < 0.01; ***P < 0.001

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