Skip to main content
Fig. 7 | Cell & Bioscience

Fig. 7

From: VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells

Fig. 7

VHL-S65W gene signature is associated with human renal cancer severity and prognosis. A Heatmap showing the expression profiles of genes differentially influenced by VHL-S65W and directly occupied by HIF2α. BD VHL-S65P signature is strikingly elevated in human kidney cancers compared to normal kidney specimens. EH High expression of VHL-S65 signature positively correlate with elevated EMT (EG) and hypoxia signaling score (H). I Kaplan–Meier graph showing a significant association between elevated expression of the VHL-S65W signature and shorter progression-free survival in a cohort of patients with renal cancers. J, K Kaplan–Meier graphs demonstrating significant associations between elevated VHL-S65W gene signature expression and reduced disease-specific survival (J) or disease-free survival (K). L, M Kaplan–Meier plots examining the risk of shortened overall survival in kidney cancer patients with higher expression of the VHL-S65W gene signature. In IM, P values were calculated by a log-rank test

Back to article page