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Fig. 6 | Cell & Bioscience

Fig. 6

From: VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells

Fig. 6

VHL-S65P gene signature is associated with human kidney cancer progression. A Heatmap showing the expression profiles of genes differentially altered by VHL-S65P and directly bound by HIF2α. B ChIP-qPCR confirmation of HIF2α chromatin binding at the representative genes of VHL mutant signature in the cells expressing WT or mutant VHL (n = 3 replicates). C Analysis of mRNA expression of the VHL mutant signature genes in 786-O cells expressing VHL WT or mutants using quantitative RT-PCR (n = 3). DE VHL-S65P signature is significantly upregulated in human renal cancers compared to normal kidney samples. FI The expression of VHL-S65 signature positively correlate with EMT score (FH) and hypoxia signaling score (I)

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