Fig. 1
From: TRPM8 deficiency attenuates liver fibrosis through S100A9-HNF4α signaling
TRPM8 is highly expressed in the livers of cirrhotic patients and fibrotic mice. A Representative images of immunohistochemical staining of TRPM8 in healthy control and cirrhotic human liver tissues, and its statistical summary. Scale bars, 100 μm. B Cirrhotic patients were divided into three different categories according to their etiologies: chronic hepatitis B (CHB), alcohol-related liver disease (ALD), and autoimmune hepatitis (AIH). C, D Immunoblotting analysis of hepatic TRPM8 expression in CCl4- and BDL-induced liver fibrosis model (n = 3 per group). The results are expressed as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001