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Fig. 1 | Cell & Bioscience

Fig. 1

From: Heterogeneity of mesenchymal stem cell-derived extracellular vesicles is highly impacted by the tissue/cell source and culture conditions

Fig. 1

adapted from Gustafson et al. [7]

Subtypes of extracellular vesicles in eukaryotic cells. Cells can release three different types of EVs: (i) apoptotic bodies are generated during programmed cell death by membrane blebbing, (ii) microvesicles are shed by outward budding and fission of the plasma membrane, and (iii) exosomes are formed as intraluminal vesicles via inward budding of early endosomes, giving rise to multivesicular bodies (MVBs), which either fuse with lysosomes or with the plasma membrane, leading to the secretion of exosomes. Illustration

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