Table 1 Evaluation of the behaviour of TNHs nanoconstructs in biological media
Stability in cell culture medium | |||||
|---|---|---|---|---|---|
Time | (a) Mean size (nm) | (b) Concentration (part/mL) | (c) Percentage decrease (as percentage) from initial t0 value %co-ZnO | ||
Medium | TNHs | Medium | TNHs | ||
t0 | 86 ± 4 | 128 ± 8 | 3.88 × 109 ± 3.44 × 108 | 3.96 × 109 ± 5.57 × 108 | – |
1 h | 79 ± 5 | 144 ± 4 | 5.18 × 109 ± 1.05 × 108 | 6.42 × 109 ± 4.25 × 108 | − 17 ± 3% |
24 h | 78 ± 6 | 138 ± 3 | 3.60 × 109 ± 1.50 × 108 | 7.52 × 109 ± 1.40 × 109 | − 20 ± 4% |
48 h | 83 ± 4 | 135 ± 13 | 4.60 × 109 ± 7.73 × 108 | 5.66 × 109 ± 1.23 × 109 | − 15 ± 10% |
(d) Clotting time in human recovered plasma | ||||
|---|---|---|---|---|
|  | Ctrl (plasma) | Plasma + Phys. solution | Plasma + Phys. solution + water | Plasma + Phys. solution + water and TNHs |
Time (min) | 10.3 ± 0.3 | 10.4 ± 0.3 | 10.7 ± 0.5 | 9.5 ± 0.6 |