Fig. 2
Downregulated LYPLAL1-AS1 in senescent hADSCs. A Heatmap of differentially expressed genes between P10 and P3 hADSCs from three donors. Red arrow indicates LYPLAL1-AS1. B Genomic location of LYPLAL1-AS1. C qRT-PCR of LYPLAL1-AS1 in hADSCs during replicative senescence at different passages. D qRT-PCR of LYPLAL1-AS1 in hADSCs during replicative senescence at different passages. qRT-PCR of LYPLAL1-AS1 in H2O2-treated hADSCs. E qRT-PCR of LYPLAL1-AS1 in young adult (median age: 27 years, n = 21) and middle-aged healthy donors (median age: 53 years, n = 21). qPCR data were normalized to GAPDH, n = 3. Data are shown as mean ± SD from three independent experiments; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001