Fig. 2From: 3D and organoid culture in research: physiology, hereditary genetic diseases and cancerSchematic view of the multilineage nature of the tumor microenvironment. Fibroblasts, NK cells and macrophages adjacent to cancer cells secrete cytokines and other signaling molecules that stimulate vascular endothelial cells and activate immune cells, which in response attack tumor antigen-displaying cancer cellsBack to article page