Fig. 6
From: BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting super-enhancers in neuroblastoma
In vivo GNE987 treatment caused tumour necrosis in NB xenograft models. A Schematic of the experimental design. Mice bearing luciferase-labelled NB xenograft tumours were treated with intraperitoneal injections of 0.25 mg/kg GNE987 every other day once their tumour luminescence flux reached 3–5 × 105 photons/second via bioluminescent imaging (BLI). B Representative sequential BLI images of the tumour bearing mice in the control group or the GNE987 treatment group taken at 7, 14, and 21 days after subcutaneous implantation of NB cells. Scale is in photons/second. n = 6. *p < 0.05. C Photograph of excised tumours from the mice in the GNE987 treatment group and the control group at d 21. Scale bar, 1 cm. D Weight changes in the tumour bearing mice in the GNE987 treatment group and the control group. E The average tumor weight of the excised tumours at d 21. F Tumour growth curves of tumour-bearing mice in the GNE987 treatment group and the control group in response to different treatments. ***p < 0.001, ****p < 0.0001. G H&E staining of organs in the mice in the GNE987 treatment group. Scale bar, 200 μm. H Representative images of IHC staining with the indicated antibodies in tumours harvested from the mice in the GNE987 treatment group and the control group. Scale bar, 200 μm