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Fig. 4 | Cell & Bioscience

Fig. 4

From: BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting super-enhancers in neuroblastoma

Fig. 4

GNE987 induced the degradation of a BET protein and N-myc or C-myc. A Western blotting analysis of BET proteins and N-myc or C-myc levels in the NB cells treated with vehicle (DMSO) or. increasing doses of GNE987 for 24 h. B Protein levels of BET and N-myc in the SK-N-BE (2) cells treated with vehicle (DMSO), GNE987, or JQ1. The BRD4 protein level was normalized against that of GAPDH. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; ns, not significant

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