Fig. 1
From: BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting super-enhancers in neuroblastoma
High BRD4 expression in NB was associated with poor prognosis. A Kaplan–Meier analysis of the correlation of BRD4 high or low expression with the OS of the patients with NB [generated from R2 Genomics Analysis and Visualization Platform (http://r2.amc.nl)]. Median survival time was used as a cutoff point for defining high or low expression; p < 0.001. B Correlation between BRD4 and MYCN mRNA expression in NB [generated from R2 Genomics Analysis and Visualization Platform (http://r2.amc.nl)]; p < 0.001. C Representative images of IHC staining of the BRD4 protein on a tissue microarray constructed from 27 NB tissues and seven matched normal tissues. Histological scores were determined according to the intensity of BRD4 staining. PN, peripheral neuron; NB, neuroblastoma. ***p < 0.001. D Dose–response curves of five BRD4 inhibitors (GNE987, JQ1, dBET, MZ1, ARV825) at the indicated concentrations in SK-N-BE (2) or SH-SY5Y cells. Data are represented as the mean ± SD