Skip to main content

Table 1 2SMR estimates of the causality between diabetes and AD

From: Causal association evaluation of diabetes with Alzheimer's disease and genetic analysis of antidiabetic drugs against Alzheimer's disease

Study Method Number of SNPs b se P-value OR 95% CI Cochran’s Q statistic (P-value) MR-egger intercept (P-value)
T1D Inverse variance weighted 4 0.04 0.01 2.90E−03 1.04 1.01–1.06 3.66 (0.30)  
MR Egger 4 0.06 0.02 0.08 1.06 1.03–1.10 0.94 (0.63) − 0.02 (0.24)
Weighted median 4 0.04 0.01 8.83E−04 1.04 1.02–1.07   
Weighted mode 4 0.04 0.01 0.04 1.04 1.02–1.07   
T2D Inverse variance weighted 11 0.29 0.12 0.02 1.34 1.05–1.70 9.43 (0.49)  
MR Egger 11 0.70 0.40 0.11 2.01 0.93–4.36 8.28 (0.51) − 0.02 (0.31)
Weighted median 11 0.18 0.17 0.28 1.20 0.86–1.68   
Weighted mode 11 0.04 0.23 0.88 1.04 0.65–1.64