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Table 1 2SMR estimates of the causality between diabetes and AD

From: Causal association evaluation of diabetes with Alzheimer's disease and genetic analysis of antidiabetic drugs against Alzheimer's disease

Study

Method

Number of SNPs

b

se

P-value

OR

95% CI

Cochran’s Q statistic (P-value)

MR-egger intercept (P-value)

T1D

Inverse variance weighted

4

0.04

0.01

2.90E−03

1.04

1.01–1.06

3.66 (0.30)

 

MR Egger

4

0.06

0.02

0.08

1.06

1.03–1.10

0.94 (0.63)

− 0.02 (0.24)

Weighted median

4

0.04

0.01

8.83E−04

1.04

1.02–1.07

  

Weighted mode

4

0.04

0.01

0.04

1.04

1.02–1.07

  

T2D

Inverse variance weighted

11

0.29

0.12

0.02

1.34

1.05–1.70

9.43 (0.49)

 

MR Egger

11

0.70

0.40

0.11

2.01

0.93–4.36

8.28 (0.51)

− 0.02 (0.31)

Weighted median

11

0.18

0.17

0.28

1.20

0.86–1.68

  

Weighted mode

11

0.04

0.23

0.88

1.04

0.65–1.64