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Fig. 1. | Cell & Bioscience

Fig. 1.

From: Causal association evaluation of diabetes with Alzheimer's disease and genetic analysis of antidiabetic drugs against Alzheimer's disease

Fig. 1.

2SMR analysis of the causal association between T1D and the risk of AD. a Scatter plot. The slope of the line corresponds to a causal estimate using each of the four different methods. b Funnel plot. The vertical line shows a causal estimate using all SNPs combined into a single instrument for each of two different methods. c Forest plot. Each black dot represents the MR estimate of each SNP using the wald ratio, and the horizontal line represents the 95% CI. The red points show a combined causal estimate using all SNPs in a single instrument, including the 2SMR estimates of IVW and MR-Egger. d Leave-one-out sensitivity analysis. Each black dot represents the result of MR-IVW excluding that particular SNP, and the red dot depicts the IVW estimate using all SNPs

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