Fig. 1
From: The dual role of p62 in ferroptosis of glioblastoma according to p53 status
P62 promotes ferroptosis in p53-mutant GBM cells but inhibits ferroptosis in p53-wild-type GBM cells. A U118, U251 or U87 cells were transfected with pcDNA3.1 or HA-P62 plasmids, followed by DMSO or erastin treatment. Cell death were determined by trypan blue staining. B U118 or U87 control cells and p62-overexpressed clones treated with erastin were subjected to transmission electron microscopy. C The levels of MDA were measured in U251 or U87 cells, which were transfected with pcDNA3.1 or HA-P62 plasmids, followed by DMSO or erastin treatment. pcDNA3.1: the control group. HA-P62: p62 overexpression group