Fig. 7

The ECM of mice with silicosis was involved in the detachment of lung fibroblasts. A, B According to the ECM proteomics results, 270 proteins showed differential expression (143 proteins were upregulated; 127 proteins were downregulated) in ECM derived from lung tissues of mice with silicosis (n = 3) with FC = 2. C, D GO analysis of the identified downregulated proteins: the top 30 GO entries were mainly involved in the biological process of cell adhesion, the major cellular components were related to collagen, and the main molecular function was the recognition of protein binding. E KEGG analysis of the downregulated proteins: among the top 20 enriched signaling pathways, mediating ECM receptor recognition and adhesion-related signaling were the most enriched pathways