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Fig. 4 | Cell & Bioscience

Fig. 4

From: YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner

Fig. 4

Depletion of YTHDF1 inhibits the growth of breast cancer cells in vivo. NOD/SCID mice (5 per group) were transplanted with MCF-7 cells (2 * 106) transduced with sh-NC or sh-YTHDF1#2. A Tumor volumes in sh-NC or sh-YTHDF1#2 group at indicated days. B Representative images and C the weight of tumors in sh-NC or sh-YTHDF1#2 group at day 49. D The expression of EMT-related proteins and E cell cycle analysis in xenograft that transduced with sh-NC or sh-YTHDF1. F The number of visible lung metastasis nodules and representative images of lung HE staining slices. (T stands for metastasis and N for normal lung tissues). All data were presented as means ± SD of at least three independent repetitions. Values are significant at *P < 0.05, **P < 0.01, ***P < 0.001 as indicated

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