Table 1 lncRNAs involved in cancer therapy-induced cardiotoxicity
From: Long non-coding RNAs and microRNAs as crucial regulators in cardio-oncology
lncRNA | Orthologs | Type | Drug | Expression | Targets | Cell type | Biological effect | Ref. |
|---|---|---|---|---|---|---|---|---|
CMDL-1 | Rattus norvegicus | Unknown | DOX | Down | Drp-1 | CMs | Mitochondrial fission and apoptosis | [139] |
SOX2-OT | Homo sapiens Mus musculus | Overlapping | DOX | Up | miR-942-5p | CMs | apoptosis | [231] |
HOXB-AS3 | Homo sapiens | Antisense | DOX | Up | miRNA-875-3p | CMs | Protects CMs | [350] |
NEAT1 | Homo sapiens Mus musculus | Intergenic | As2O3 | Up | miR-124/NF-κB | CMs | Protects CMs | [149] |
MALAT1/NEAT2 | Homo sapiens Mus musculus | Intergenic | DOX | Up | miR-92a-3p/ATG4a miR-144–39 | CMs | Mitochondrial metabolism & autophagy | |
lincRNA-p21 | Homo sapiens Mus musculus | Intergenic | DOX | Up | Wnt/β-catenin | CMs | silencing lincRNA-p21 effectively protects against DOX cardiotoxicity by regulating the Wnt/β-catenin signaling pathway and decreasing oxidant stress | [351] |
NEAT1 | Homo sapiens Mus musculus | Intergenic | DOX | Up | let-7f-2-3p | CMs | Attenuated cardiotoxicity via XPO1-mediated HAX-1 nuclear export | [151] |
FOXC2-AS1 | Homo sapiens | Antisense | DOX | Up | WISP1 | CMs | Promoted DOX resistance and reduces the DOX-induced CM injury | [352] |
PVT1 | Homo sapiens Mus musculus | Intergenic | DOX | Down | miR-187-3p | CMs | Decreased the apoptosis of CMs | [353] |
NEAT1 | Homo sapiens Mus musculus | Intergenic | DOX | Up | miR-221-3p | CM and exosomeMIF | Exosomal LncRNA–NEAT1 derived from MIF-treated mesenchymal stem cells protected | [153] |
KCNQ1OT1 | Homo sapiens Mus musculus | Antisense | As2O3 | Down | Kcnq1 | In vivo: mouse In vitro: CM | QT interval prolongation | [354] |
SNHG1 | Homo sapiens | Intergenic | DOX | Overexpression | miR-195/Bcl-2 | CMs | Protected the CMs from DOX toxicity | [355] |
LINC00339 | Homo sapiens | Intergenic | DOX | Knockdown | miR-484 | CMs | Improved cells proliferation activity and reduced CM apoptosis through miR-484 axis | [356] |
CHRF | Mus musculus | Intronic | DOX | Knockdown | TGF-β1 | CMs | Improved DOX-induced heart failure by regulating TGF-β1 | [246] |
TINCR | Homo sapiens Mus musculus Rattus norvegicus | Intergenic | DOX | Knockdown | NLRP3, IGF2BP1 | CMs and heart tissues | Reversed the DOX-induced pyroptosis both in vitro and in vivo | [267] |