Skip to main content

Table 1 lncRNAs involved in cancer therapy-induced cardiotoxicity

From: Long non-coding RNAs and microRNAs as crucial regulators in cardio-oncology

lncRNA Orthologs Type Drug Expression Targets Cell type Biological effect Ref.
CMDL-1 Rattus norvegicus Unknown DOX Down Drp-1 CMs Mitochondrial fission and apoptosis [139]
SOX2-OT Homo sapiens
Mus musculus
Overlapping DOX Up miR-942-5p CMs apoptosis [231]
HOXB-AS3 Homo sapiens Antisense DOX Up miRNA-875-3p CMs Protects CMs [350]
NEAT1 Homo sapiens Mus musculus Intergenic As2O3 Up miR-124/NF-κB CMs Protects CMs [149]
MALAT1/NEAT2 Homo sapiens Mus musculus Intergenic DOX Up miR-92a-3p/ATG4a
miR-144–39
CMs Mitochondrial metabolism & autophagy [201, 205]
lincRNA-p21 Homo sapiens Mus musculus Intergenic DOX Up Wnt/β-catenin CMs silencing lincRNA-p21 effectively protects against DOX cardiotoxicity by regulating the Wnt/β-catenin signaling pathway and decreasing oxidant stress [351]
NEAT1 Homo sapiens Mus musculus Intergenic DOX Up let-7f-2-3p CMs Attenuated cardiotoxicity via XPO1-mediated HAX-1 nuclear export [151]
FOXC2-AS1 Homo sapiens Antisense DOX Up WISP1 CMs Promoted DOX resistance and reduces the DOX-induced CM injury [352]
PVT1 Homo sapiens Mus musculus Intergenic DOX Down miR-187-3p CMs Decreased the apoptosis of CMs [353]
NEAT1 Homo sapiens Mus musculus Intergenic DOX Up miR-221-3p CM and exosomeMIF Exosomal LncRNA–NEAT1 derived from MIF-treated mesenchymal stem cells protected [153]
KCNQ1OT1 Homo sapiens Mus musculus Antisense As2O3 Down Kcnq1 In vivo: mouse
In vitro: CM
QT interval prolongation [354]
SNHG1 Homo sapiens Intergenic DOX Overexpression miR-195/Bcl-2 CMs Protected the CMs from DOX toxicity [355]
LINC00339 Homo sapiens Intergenic DOX Knockdown miR-484 CMs Improved cells proliferation activity and reduced CM apoptosis through miR-484 axis [356]
CHRF Mus musculus Intronic DOX Knockdown TGF-β1 CMs Improved DOX-induced heart failure by regulating TGF-β1 [246]
TINCR Homo sapiens Mus musculus
Rattus norvegicus
Intergenic DOX Knockdown NLRP3, IGF2BP1 CMs and heart tissues Reversed the DOX-induced pyroptosis both in vitro and in vivo [267]