Table 1 The PTM-associated clinical trials with published articles in breast cancer patients
From: Unconventional protein post-translational modifications: the helmsmen in breast cancer
Type of PTMs | Identifiers/Ref | Title | Phase | Diseases | Intervention | Status |
|---|---|---|---|---|---|---|
Acetylation | NCT01105312 [233] | Panobinostat and Letrozole in Treating Patients With Metastatic Breast Cancer | I/II | Breast Cancer | Drug:letrozole Drug:panobinostat | Completed |
| Â | NCT00365599 [237] | Phase II Trial of SAHA & Tamoxifen for Patients With Breast Cancer | II | Breast Cancer | Drug:Vorinostat Drug: Tamoxifen | Completed |
| Â | NCT00616967 [254] | Carboplatin and Nab-Paclitaxel With or Without Vorinostat in Treating Women With Newly Diagnosed Operable Breast Cancer | II | Breast Cancer | Drug:carboplatin Drug: paclitaxel albumin-stabilized nanoparticle formulation Drug: vorinostat | Active, not recruiting |
| Â | NCT02395627 [241] | Reversing Therapy Resistance With Epigenetic-Immune Modification | II | Breast Neoplasms | Drug: Tamoxifen Drug: Vorinostat Drug:Pembrolizumab | Terminated |
| Â | NCT00395655 [236] | Hydralazine and Valproate Added to Chemotherapy for Breast Cancer | II | Locally Advanced Breast Cancer | Drug: Hydralazine Drug: Valproic Acid | Terminated |
| Â | NCT02482753 [239] | Trial of Chidamide in Combination With Exemestane in Patients With Advanced Breast Cancer | III | Breast Cancer | Drug: Chidamide Drug: exemestane | Active, not recruiting |
| Â | NCT02833155 [235] | Entinostat in Chinese Postmenopausal Women Patients With Locally Recurrent or Metastatic Breast Cancer | I | Breast Cancer | Drug: Entinostat Drug: Exemestane | Completed |
|  | NCT00676663 [238] | Study to Evaluate Exemestane With and Without Entinostat (SNDX-275) in Treatment of Postmenopausal Women With Advanced Breast Cancer | II | Breast Cancer ER + Breast Cancer | Drug: Entinostat Drug: Exemestane | Completed |
| Â | NCT04296942 [255] | BN-Brachyury, Entinostat, Adotrastuzumab Emtansine and M7824 in Advanced Stage Breast Cancer (BrEAsT) | I | Breast Cancer Metastatic Breast Cancer | Drug: Entinostat Biological: M7824 Biological: Ado-trastuzumab emtansine | Completed |
| Â | NCT01349959 [252] | Azacitidine and Entinostat in Treating Patients With Advanced Breast Cancer | II | Male Breast Carcinoma Recurrent Breast Carcinoma | Drug: Azacitidine Drug: Entinostat | Active, not recruiting |
| Â | NCT02115282 | Entinostat in Patients With Recurrent Advanced Hormone Receptor-Positive Breast Cancer | III | Recurrent Breast Carcinoma | Drug: Entinostat Drug: Exemestane Drug: Goserelin Acetate | Active, not recruiting |
| Â | NCT02623751 [234] | Study of KHK2375 in Subjects With Advanced or Recurrent Breast Cancer | I | Breast Cancer | Drug: entinostat Drug: Exemestane | Active, not recruiting |
Glycosylation | NCT00096707 [232] | Dose Escalation Trial of 2-Deoxy-D-Glucose (2DG) in Subjects With Advanced Solid Tumors | I | Lung Cancer Breast Cancer Pancreatic Cancer Head and Neck Cancer Gastric Cancer | Drug: 2-DG | Completed |