Skip to main content

Table 1 The PTM-associated clinical trials with published articles in breast cancer patients

From: Unconventional protein post-translational modifications: the helmsmen in breast cancer

Type of PTMs Identifiers/Ref Title Phase Diseases Intervention Status
Acetylation NCT01105312
[233]
Panobinostat and Letrozole in Treating Patients With Metastatic Breast Cancer I/II Breast Cancer Drug:letrozole
Drug:panobinostat
Completed
  NCT00365599
[237]
Phase II Trial of SAHA & Tamoxifen for Patients With Breast Cancer II Breast Cancer Drug:Vorinostat
Drug: Tamoxifen
Completed
  NCT00616967
[254]
Carboplatin and Nab-Paclitaxel With or Without Vorinostat in Treating Women With Newly Diagnosed Operable Breast Cancer II Breast Cancer Drug:carboplatin
Drug: paclitaxel albumin-stabilized nanoparticle formulation
Drug: vorinostat
Active, not recruiting
  NCT02395627
[241]
Reversing Therapy Resistance With Epigenetic-Immune Modification II Breast Neoplasms Drug: Tamoxifen
Drug: Vorinostat
Drug:Pembrolizumab
Terminated
  NCT00395655
[236]
Hydralazine and Valproate Added to Chemotherapy for Breast Cancer II Locally Advanced Breast Cancer Drug: Hydralazine Drug: Valproic Acid Terminated
  NCT02482753
[239]
Trial of Chidamide in Combination With Exemestane in Patients With Advanced Breast Cancer III Breast Cancer Drug: Chidamide
Drug: exemestane
Active, not recruiting
  NCT02833155
[235]
Entinostat in Chinese Postmenopausal Women Patients With Locally Recurrent or Metastatic Breast Cancer I Breast Cancer Drug: Entinostat
Drug: Exemestane
Completed
  NCT00676663
[238]
Study to Evaluate Exemestane With and Without Entinostat (SNDX-275) in Treatment of Postmenopausal Women With Advanced Breast Cancer II Breast Cancer
ER + Breast Cancer
Drug: Entinostat
Drug: Exemestane
Completed
  NCT04296942
[255]
BN-Brachyury, Entinostat, Adotrastuzumab Emtansine and M7824 in Advanced Stage Breast Cancer (BrEAsT) I Breast Cancer
Metastatic Breast Cancer
Drug: Entinostat
Biological: M7824
Biological: Ado-trastuzumab emtansine
Completed
  NCT01349959
[252]
Azacitidine and Entinostat in Treating Patients With Advanced Breast Cancer II Male Breast Carcinoma
Recurrent Breast Carcinoma
Drug: Azacitidine
Drug: Entinostat
Active, not recruiting
  NCT02115282
[253, 240]
Entinostat in Patients With Recurrent Advanced Hormone Receptor-Positive Breast Cancer III Recurrent Breast Carcinoma Drug: Entinostat
Drug: Exemestane
Drug: Goserelin Acetate
Active, not recruiting
  NCT02623751
[234]
Study of KHK2375 in Subjects With Advanced or Recurrent Breast Cancer I Breast Cancer Drug: entinostat
Drug: Exemestane
Active, not recruiting
Glycosylation NCT00096707
[232]
Dose Escalation Trial of 2-Deoxy-D-Glucose (2DG) in Subjects With Advanced Solid Tumors I Lung Cancer
Breast Cancer
Pancreatic Cancer
Head and Neck Cancer
Gastric Cancer
Drug: 2-DG Completed