Fig. 5

Identification of subnetwork and core genes associated with SARS-CoV-2 infection and platelet activation. A The subnetwork associated with SARS-CoV-2 infection and platelet activation in modules-2, -8, -15 and -16. The red round border indicates mRNAs only in the ‘COVID-19 pathway’; blue round border indicates mRNAs only in ‘platelet activation pathway’; gray round border indicates mRNAs both in ‘platelet activation’ and ‘COVID-19’ pathways. B Pearson’s correlation analysis was estimated among the core mRNAs. The size of the circle scales with the correlation magnitude and the darker the color, the larger the magnitude of the correlation coefficient. Red and blue represent positive and negative correlations, respectively. The upper triangular matrix and the lower triangular matrix represent the correlation coefficients in healthy and COVID-19 samples, respectively. C Protein–protein interaction network analysis among the core mRNAs. D Schematic diagram illustrating the SARS-CoV-2-induced activation of platelets and subsequent enhanced occurrence of thrombosis in COVID-19 patients. The red and black arrows indicate the pathways of SARS-CoV-2 infection and platelet activation, respectively. The dashed line indicates the indirect action and the solid line indicates the direct action. SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; COVID-19, coronavirus disease 2019