Insight into the mitochondrial unfolded protein response and cancer: opportunities and challenges

Wang, Ge; Fan, Yumei; Cao, Pengxiu; Tan, Ke

doi:10.1186/s13578-022-00747-0

Cell & Bioscience

Table 2 List of mitochondrial process-related genes associated with UPR^mt

From: Insight into the mitochondrial unfolded protein response and cancer: opportunities and challenges

Group	Gene name	Gene description	References
Mitochondrial large ribosomal subunits	mrpl-1	Mitochondrial ribosomal protein L1	[17, 20, 21]
	mrpl-2	Ribosomal L2 C domain-containing protein	[17, 20, 21]
	mrpl-9	39S ribosomal protein L9, mitochondrial	[17]
	mrpl-11	Putative 39S ribosomal protein L11, mitochondrial	[17]
	mrpl-50	39S ribosomal protein L50, mitochondrial	[17, 21]
Mitochondrial small ribosomal subunits	mrps-2	Mitochondrial ribosomal protein, S2	[17, 20, 21]
	mrps-5	Putative 28S ribosomal protein S5, mitochondrial	[17, 20, 21]
	mrps-18b	Mitochondrial ribosomal protein, S18b	[17, 20]
	mrps-24	28S ribosomal protein S24, mitochondrial	[17]
	mrps-35	MRP-S28 domain-containing protein	[17, 20]
Complex I ETC	nuo-3	NADH ubiquinone oxidoreductase	[17, 21]
	gas-1	Putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 2	[17, 20]
	lpd-5	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	[17, 21]
Complex V ETC	atp-2	ATP synthase subunit beta, mitochondrial	[17, 20, 21]
	hpo-18	Mitochondrial F1F0-ATP synthase, subunit epsilon/ATP15	[17, 20]
	asb-1	ATP synthase subunit b	[17]
Mitochondrial ETC assembly factors	sco-1	Putative cytochrome C oxidase assembly protein	[17, 20]
Mitochondrial ETC assembly factors	cox-18	Cytochrome oxidase assembly protein	[17]
Mitochondrial import	dnj-21	Mitochondrial import inner membrane translocase subunit TIM14	[17, 20, 21]
Mitochondrial import	gop-3	SAM50-like protein gop-3	[17]
Lipid metabolism	acdh-13	Acyl CoA dehydrogenase	[17]
Lipid metabolism	mecr-1	Enoyl-[acyl-carrier-protein] reductase	[17, 21]
Translation elongation factors	tufm-1	Elongation factor Tu, mitochondrial	[17, 20]
Translation elongation factors	gfm-1	Elongation factor G, mitochondrial	[17]
Mitochondrial proteases	spg-7	AFG3-like protein spg-7	[17, 21]
Mitochondrial proteases	atad-3	ATPase family AAA domain-containing protein 3	[17]
Mitochondrial chaperones	hsp-60	Chaperonin homolog Hsp-60, mitochondrial	[17, 20, 21]
Mitochondrial chaperones	phb-2	Mitochondrial prohibitin complex protein 2	[17, 20, 21]
Mitochondrial transcription	hoe-1	Ribonuclease Z	[17]

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ISSN: 2045-3701

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