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Fig. 8 | Cell & Bioscience

Fig. 8

From: The integrin beta1 modulator Tirofiban prevents adipogenesis and obesity by the overexpression of integrin-linked kinase: a pre-clinical approach in vitro and in vivo

Fig. 8

Putative mechanisms of TF-INTB1-ILK action. TF binds to adipocyte INTB1, depolymerizes F-actin and reduces the TG content on the lipid droplet. Adipogenesis-related genes are transcriptionally downregulated while lipolysis, thermogenesis and ILK genes are upregulated. ILK presence is part of the gear for TF function. Therefore, WAT adipocytes transdifferentiate to catabolic/beige phenotype to reduce WAT hypertrophy and obesity

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Cell & Bioscience

ISSN: 2045-3701

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