Fig. 2
From: Turning the tide on Alzheimer’s disease: modulation of γ-secretase
APP processing by γ-secretase. β-secretase cleaves APP to generate βCTF (C99) and release soluble APP (sAPPβ). Afterwards γ-secretase cleaves βCTF between Aβ49 or Aβ48 (ε-cleavage), resulting in two product lines. Further processing (ζ- and γ- cleavages) generates Aβ peptides released into the extracellular space. Created with BioRender.com