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Fig. 4 | Cell & Bioscience

Fig. 4

From: The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases

Fig. 4

The mechanisms of NRF2 activation and antioxidation. KEAP1, an E3 ligase of NRF2, can be directly oxidized and recruited by SQSTM1 to autophagosomes for degradation. Liberated NRF2 can induce the gene expression of the antioxidant genes Sqstm1, Sesn2 and Pink. The induced SQSTM1 is phosphorylated to interrupt the binding between KEAP1 and NRF2 for further positive feedback activation of NRF2. The released KEAP1 and induced SESN2 and PINK promote mitophagy to remove damaged mitochondria

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Cell & Bioscience

ISSN: 2045-3701

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