Fig. 8
(Modified from Faundes et al. [159])
Implication of eIF5A in mendelian disorders. a Evolutionary conservation of residues affected by variants (delimited by yellow rectangles) is shown in five species. b The EIF5A variants are located in the functional sites and domains of eIF5A. c In silico modelling of missense variants (red spheres) supports their deleterious nature due to their proximity with the binding E-site of the 60S ribosomal subunit with adjacent P-site (green) and A-site tRNAs (pink)