Fig. 7From: The eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological rolesRole of eIF5A in ischemia tolerance, application to kidney transplantation and stroke. a Identification of the polyamine pathway and the hypusination of eIF5A as a pharmacological target in hypoxia tolerance. b Application of the concept in kidney transplantation in which the kidney's donor has been pretreated with GC7. The beneficial effect of GC7 is shown by the drastic decrease of the plasma creatinine level. c Application of the concept to the mouse model of transient cerebral focal ischemia. Mouse were treated post-stroke with GC7. The improvement of motor and cognitive behavior post-stroke was revealed by the classical Morris water maze test in which GC7 treated mice have found the immerged platform more rapidly than control miceBack to article page